Pregnancy Outcomes

Pregnancy Outcome Following Antibiotic Lavage and
Intravenous Antibiotic Combination Therapy
After Primary or Multiple Failed IVF Cycles

• Total Number of Patients: 52 (all primary infertility and had at least 1 previous failed IVF cycle)
• Number of patients who returned for subsequent IVF cycles: 36
• Number of patients who pregnant/delivered following subsequent IVF cycle: 19
• Number of patients who did not go for subsequent IVF cycle: 16
• Number of patients with spontaneous pregnancy: 4

Successful Deliveries

By age group:

• <37: 10/5 (50%)
• 37-39: 10/5 (50%)
• 40-43: 12/8 (66%
• >43: 3/1 (33%)

By number of previous trials:

• 1: 7/6 (85%)
• 2-4: 20/11 (55%)
• >5: 8/2 (25%)

Chlamydia status before IV therapy:

• 52/24 (46%).
• Out of 36 who went back for IVF 16 (44%) were positive.
• Delivery for Chlamydia positive patients: 16/11 (72%).
• Failed subsequent IVF cycles for Chlamydia positive patients: 16/4 (25%)
• Three out of four patients who achieved spontaneous pregnancies post antibiotic therapy were originally Chlamydia positive.

Important points:

• The less failed IVF cycles you had the more likely that my therapy will be followed by a successful IVF, suggesting an infectious cause of infertility that is aggravated through subsequent failed cycles.
• The four spontaneous pregnancies make a strong case for using antibiotics first before resorting to IVF.
• As I always suspected, age is not as significant an issue as it is currently believed.
• Chlamydia seems to emerge as a very important pathogen. Regretfully testing is often not performed or if performed and positive reading given the subsequent antibiotic therapy is highly inadequate. 
• I cannot finalize the data until November 2005 when the last patient is expected to deliver. As data keep coming in I'll provide you with updates.
• So far, however:
  • No IUGR
  • For all babies delivered total of 8 days in NICU for "observation"
  • Cost benefit analysis of IVF and my antibiotic therapy favors the antibiotics

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